Ethical and Methodological Principles of Genetic Research Involving Psychiatric Patients
https://doi.org/10.17803/lexgen-2025-4-2-94-106
Abstract
Over the past 30 years, over 6,000 human genes have been investigated for their association with the development of central nervous system (CNS) diseases. However, such studies offer poor reproducibility due to methodological differences, heterogeneous and often small sample sizes, as well as the significant influence of genetic variation related to ethnic diversity. Psychiatric disorders may be characterized by their polygenic inheritance, i.e., involving multiple candidate genes. Thus, while the contribution of a specific gene to a particular psychiatric disorder’s pathogenesis is likely to be very small, candidate genes have been identified as partially influencing disease onset. The article sets out fundamental ethical and methodological principles for conducting genetic research and establishing biomaterial repositories – or biobanks. When involving psychiatric patients, such principles must take into account the inherent vulnerability of this group. The conclusions presented in this work may serve as a foundation for developing methodological recommendations and guidelines.
About the Authors
Z. Sh. Ashurov
Tashkent Medical Academy ; Republican Specialized Scientific and Practical Medical Center for Mental Health
Uzbekistan
Uzbekistan
Zarifjon Sh. Ashurov, Doctor of Science (Medicine), Professor, Head of the Department of Psychiatry and Narcology; Chief Psychiatrist and Narcologist of the Ministry of Health of the Republic of Uzbekistan; Head; President of the Association of Psychiatrists of Uzbekistan
Tashkent
I. I. Khayredinova
Tashkent Medical Academy ; Republican Specialized Scientific and Practical Medical Center for Mental Health
Uzbekistan
Uzbekistan
Inara I. Khayredinova, Candidate of Science (Medicine), Head of Innovation Technologies Department
Tashkent
L. N. Khegay
Republican Specialized Scientific and Practical Medical Center for Mental Health
Uzbekistan
Uzbekistan
Lyubov N. Khegay, Candidate of Science (Medicine), Associate Professor, Head of Innovative Technologies Department
Tashkent
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For citations:
Ashurov Z.Sh., Khayredinova I.I., Khegay L.N. Ethical and Methodological Principles of Genetic Research Involving Psychiatric Patients. Lex Genetica. 2025;4(2):94-106. (In Russ.) https://doi.org/10.17803/lexgen-2025-4-2-94-106
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